Different roles of SEMA4D in mediating snaling ... - ResearchGate

sma4dSMAD4 is the only common SMAD in TGF-β snaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here thatEvans and colleagues describe a novel immunomodulatory function of semaphorin 4D (SEMA4D) and show that blocking SEMA4D enhances immune infiltration into tumor